《蛋白質科學》是蛋白質學會的旗艦期刊，為發表有關蛋白質分子所有科學方面的原始報告提供了一個國際論壇。該雜志發表了來自世界各地的頂尖科學家的論文，報告了在最廣義上對蛋白質的理解方面的進展。蛋白質科學的目標是通過跨越既定的學科界限，聚焦于“以蛋白質為中心”的科學，從而統一這一領域。該雜志包括蛋白質的結構、功能和生化意義，它們在分子和細胞生物學、遺傳學和進化中的作用，以及它們的調控和作用機制。特別感興趣的題目包括但不限于:■蛋白質結構和用化學、生物物理和重組方法確定蛋白質結構的策略■肽■蛋白質域■蛋白質折疊和分子動力學新型隔離程序■酶的作用和調節■蛋白質與核酸、脂類、配體和其他蛋白質的相互作用■受體介導的信號轉導等跨膜現象■蛋白質在復制、超分子組裝、免疫反應、發育等生物學過程中的功能■蛋白質的轉運、合成和分選■蛋白質的識別、定位和信號轉導除了上述的研究技術，該雜志還將發表以下以蛋白質為中心的研究結果:■測序、修飾和質譜分析■cDNA、誘變和克隆■計算分析■分離與表征■熱力學和流體動力學■動力學■平衡現象蛋白質科學出版完整的原始研究論文，以及評論和書評。回憶(僅憑邀請)是一種歷史回顧，旨在概述蛋白質科學中某個特定主題是如何發展起來的。有一個特別部分，供記錄，其中載有關于該領域最近發展情況的簡要參考報告(即;本節可能突出顯示一個新的蛋白質序列或報告一個新的蛋白質結構和/或功能)。審查(僅邀請)的目的是使一般讀者熟悉迅速發展的當前感興趣的主題的現狀和未來趨勢。

Protein Science, the flagship journal of The Protein Society, serves an international forum for publishing original reports on all scientific aspects of protein molecules. The Journal publishes papers by leading scientists from all over the world that report on advances in the understanding of proteins in the broadest sense. Protein Science aims to unify this field by cutting across established disciplinary lines and focusing on “protein-centered” science.The Journal encompasses the structure, function, and biochemical significance of proteins, their role in molecular and cell biology, genetics, and evolution, and their regulation and mechanisms of action. Topics of particular interest include, but are not limited to: ■ Structure of proteins and strategies of determining protein structure by chemical, biophysical, and recombinant methods ■ Peptides ■ Protein domains ■ Protein folding and molecular dynamics ■ Novel isolation procedures ■ Enzyme action and regulation ■ Interactions of proteins with nucleic acids, lipids, ligands, and other proteins ■ Receptor-mediated signal transduction and other trans-membrane phenomena ■ The functions of proteins in replication, supramolecular assembly, immune reactions, development, and other biological processes ■ Protein trafficking, synthesis and sorting ■ Recognition, localization and signaling of proteinsIn addition to the investigative techniques aforementioned, the Journal will publish results of protein-centered work involving: ■ Sequencing, modification, and mass spectrometry ■ cDNA, mutagenesis and cloning ■ Computational analysis ■ Isolation and characterization ■ Thermodynamics and hydrodynamics ■ Kinetics ■ Equilibrium phenomenaProtein Science publishes full-length original research papers as well as reviews and book reviews. Recollections (by invitation only) are historical reviews that are intended to give an overview of how a particular topic in the science of proteins has developed. A special section, For the Record, features brief refereed reports of recent developments in the field (i.e.; this section may highlight a new protein sequence or report a new protein structure and/or function). Reviews (by invitation only) are intended to familiarize the general reader with the current status and future trends of rapidly evolving topics of current interest.